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This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. [1064 Pages, Hardcover]Read More... [...]
Thu, May 17, 2018
Source: Wiley VCH Chemistry Books Category: SCIENCE BOOKS
Addresses threats to homeland security from terrorism and emergency management from natural disasters Threats to Homeland Security, Second Edition examines the foundations of today's security environment, from broader national security perspectives to specific homeland security interests and concerns. It covers what we protect, how we protect it, and what we protect it from. In addition, the book examines threats from both an international perspective (state vs non-state actors as well as kinds of threat capabilities--from cyber-terrorism to weapons of mass destruction) and from a national perspective (sources of domestic terrorism and future technological challenges, due to globalization and an increasingly interconnected world). This new edition of Threats to Homeland Security updates previous chapters and provides new chapters focusing on new threats to homeland security today, such as the growing nexus between crime and terrorism, domestic and international intelligence collection, critical infrastructure and technology, and homeland security planning and resources--as well as the need to reassess the all-hazards dimension of homeland security from a resource and management perspective. * Features new chapters on homeland security intelligence, crime and domestic terrorism, critical infrastructure protection, and resource management * Provides a broader context for assessing threats to homeland security from the all-hazards perspective, to include terrorism and natural disasters * Examines potential targets at home and abroad * Includes a comprehensive overview of U.S. policy, strategy, and technologies for preventing and countering terrorism * Includes self-assessment areas, key terms, summary questions, and application exercises. On-line content includes PPT lessons for each chapter and a solutions key for academic adopters Threats to Homeland Security, Second Edition is an excellent introductory text on homeland security for educators, as well as a good source of training for professionals in a number of homeland security-related disciplines. [576 Pages, Softcover]Read More... [...]
Wed, May 16, 2018
Source: Wiley VCH Chemistry Books Category: SCIENCE BOOKS
Focuses entirely on demystifying the field and subject of ICME and provides step-by-step guidance on its industrial application via case studies This highly-anticipated follow-up to Mark F. Horstemeyer's pedagogical book on Integrated Computational Materials Engineering (ICME) concepts includes engineering practice case studies related to the analysis, design, and use of structural metal alloys. A welcome supplement to the first book--which includes the theory and methods required for teaching the subject in the classroom--Integrated Computational Materials Engineering (ICME) For Metals: Concepts and Case Studies focuses on engineering applications that have occurred in industries demonstrating the ICME methodologies, and aims to catalyze industrial diffusion of ICME technologies throughout the world. The recent confluence of smaller desktop computers with enhanced computing power coupled with the emergence of physically-based material models has created the clear trend for modeling and simulation in product design, which helped create a need to integrate more knowledge into materials processing and product performance. Integrated Computational Materials Engineering (ICME) For Metals: Case Studies educates those seeking that knowledge with chapters covering: Body Centered Cubic Materials; Designing An Interatomic Potential For Fe-C Alloys; Phase-Field Crystal Modeling; Simulating Dislocation Plasticity in BCC Metals by Integrating Fundamental Concepts with Macroscale Models; Steel Powder Metal Modeling; Hexagonal Close Packed Materials; Multiscale Modeling of Pure Nickel; Predicting Constitutive Equations for Materials Design; and more. * Presents case studies that connect modeling and simulation for different materials' processing methods for metal alloys * Demonstrates several practical engineering problems to encourage industry to employ ICME ideas * Introduces a new simulation-based design paradigm * Provides web access to microstructure-sensitive models and experimental database Integrated Computational Materials Engineering (ICME) For Metals: Case Studies is a must-have book for researchers and industry professionals aiming to comprehend and employ ICME in the design and development of new materials. [688 Pages, Hardcover]Read More... [...]
Wed, May 16, 2018
Source: Wiley VCH Chemistry Books Category: SCIENCE BOOKS
A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author--a noted expert in the field--includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book describes the up-to-date and state-of-the-art methods of organic synthesis that describe the use of privileged structures that are of most interest. Chapters included information on benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry. Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume: * Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them * Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry * Details many of the recent developments in organic chemistry that prepare target molecules * Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, Privileged Structures in Drug Discovery offers a current guide to organic synthesis methods to access the privileged structures of interest, and contains medicinal chemistry case studies that document their application. [560 Pages, Hardcover]Read More... [...]
Wed, May 16, 2018
Source: Wiley VCH Chemistry Books Category: SCIENCE BOOKS
A Practical, Interdisciplinary Guide to Advanced Mathematical Methods for Scientists and Engineers Mathematical Methods in Science and Engineering, Second Edition, provides students and scientists with a detailed mathematical reference for advanced analysis and computational methodologies. Making complex tools accessible, this invaluable resource is designed for both the classroom and the practitioners; the modular format allows flexibility of coverage, while the text itself is formatted to provide essential information without detailed study. Highly practical discussion focuses on the "how-to" aspect of each topic presented, yet provides enough theory to reinforce central processes and mechanisms. Recent growing interest in interdisciplinary studies has brought scientists together from physics, chemistry, biology, economy, and finance to expand advanced mathematical methods beyond theoretical physics. This book is written with this multi-disciplinary group in mind, emphasizing practical solutions for diverse applications and the development of a new interdisciplinary science. Revised and expanded for increased utility, this new Second Edition: * Includes over 60 new sections and subsections more useful to a multidisciplinary audience * Contains new examples, new figures, new problems, and more fluid arguments * Presents a detailed discussion on the most frequently encountered special functions in science and engineering * Provides a systematic treatment of special functions in terms of the Sturm-Liouville theory * Approaches second-order differential equations of physics and engineering from the factorization perspective * Includes extensive discussion of coordinate transformations and tensors, complex analysis, fractional calculus, integral transforms, Green's functions, path integrals, and more Extensively reworked to provide increased utility to a broader audience, this book provides a self-contained three-semester course for curriculum, self-study, or reference. As more scientific disciplines begin to lean more heavily on advanced mathematical analysis, this resource will prove to be an invaluable addition to any bookshelf. [864 Pages, Hardcover]Read More... [...]
Mon, May 14, 2018
Source: Wiley VCH Physics Books Category: SCIENCE BOOKS
Delivers an appropriate mix of theory and applications to help readers understand the process and problems of image and signal analysis Maintaining a comprehensive and accessible treatment of the concepts, methods, and applications of signal and image data transformation, this Second Edition of Discrete Fourier Analysis and Wavelets: Applications to Signal and Image Processing features updated and revised coverage throughout with an emphasis on key and recent developments in the field of signal and image processing. Topical coverage includes: vector spaces, signals, and images; the discrete Fourier transform; the discrete cosine transform; convolution and filtering; windowing and localization; spectrograms; frames; filter banks; lifting schemes; and wavelets. Discrete Fourier Analysis and Wavelets introduces a new chapter on frames--a new technology in which signals, images, and other data are redundantly measured. This redundancy allows for more sophisticated signal analysis. The new coverage also expands upon the discussions on spectrograms using a frames approach. In addition, the book includes a new chapter on lifting schemes for wavelets and provides a variation on the original low-pass/high-pass filter bank approach to the design and implementation of wavelets. These new chapters also include appropriate exercises and MATLAB® projects for further experimentation and practice. * Features updated and revised content throughout, continues to emphasize discrete and digital methods, and utilizes MATLAB® to illustrate these concepts * Contains two new chapters on frames and lifting schemes, which take into account crucial new advances in the field of signal and image processing * Expands the discussion on spectrograms using a frames approach, which is an ideal method for reconstructing signals after information has been lost or corrupted (packet erasure) * Maintains a comprehensive treatment of linear signal processing for audio and image signals with a well-balanced and accessible selection of topics that appeal to a diverse audience within mathematics and engineering * Focuses on the underlying mathematics, especially the concepts of finite-dimensional vector spaces and matrix methods, and provides a rigorous model for signals and images based on vector spaces and linear algebra methods * Supplemented with a companion website containing solution sets and software exploration support for MATLAB and SciPY (Scientific Python) Thoroughly class-tested over the past fifteen years, Discrete Fourier Analysis and Wavelets: Applications to Signal and Image Processing is an appropriately self-contained book ideal for a one-semester course on the subject. [464 Pages, Hardcover]Read More... [...]
Mon, May 14, 2018
Source: Wiley VCH Physics Books Category: SCIENCE BOOKS
Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. * Covers both basic science and applied technology / methods * Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects * Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development * Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria [816 Pages, Hardcover]Read More... [...]
Mon, May 14, 2018
Source: Wiley VCH Chemistry Books Category: SCIENCE BOOKS
Dieses Loseblattwerk bietet geprüfte und empfohlene Methoden und Normen für die chemische, physikalische, biologische und mineralogische Untersuchung des Bodens. Es wird getragen von allen maßgeblichen Vereinen und Verbänden, die mit der Bodenuntersuchung befasst sind. [369 Pages, Looseleaf in Binder]Read More... [...]
Thu, May 10, 2018
Source: Wiley VCH Chemistry Books Category: SCIENCE BOOKS
Interessieren Sie sich für Chemie, kennen sich aber noch nicht wirklich gut darin aus? Dann ist dies das richtige Buch für Sie. John T. Moore erklärt Ihnen anschaulich die Grundlagen der Chemie, mit Übungsaufgaben können Sie dann noch Ihr Wissen überprüfen. [380 Pages, Softcover]Read More... [...]
Thu, May 10, 2018
Source: Wiley VCH Chemistry Books Category: SCIENCE BOOKS
Klein's Organic Chemistry, Global Edition is not merely a compilation of principles, but rather, it is a disciplined method of thought and analysis. Success in organic chemistry requires mastery in two core aspects: fundamental concepts and the skills needed to apply those concepts and solve problems. This book employs a skills-based approach to bridge the gap between theory and practice. It provides extensive coverage of the principles and helps students become proficient at approaching new situations methodically based on a repertoire of skills. [1280 Pages, Softcover]Read More... [...]
Tue, May 08, 2018
Source: Wiley VCH Chemistry Books Category: SCIENCE BOOKS
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