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    Biochemistry

    [ASAP] Effect of Acceptor Chain Length and Hydrophobicity on Polymerization Kinetics of the Neisseria meningitidis Group C Polysialyltransferase

    Biochemistry
    DOI: 10.1021/acs.biochem.8b01114

    …read more

    Source:: <a href=http://feedproxy.google.com/~r/acs/bichaw/~3/NFv4jru6hM0/acs.biochem.8b01114 target="_blank" title="[ASAP] Effect of Acceptor Chain Length and Hydrophobicity on Polymerization Kinetics of the Neisseria meningitidis Group C Polysialyltransferase” rel=nofollow>ACS Biochemistry

          

    A chemical–genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase

    A chemical–genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase

    A chemical–genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase, Published online: 14 January 2019; doi:10.1038/s41589-018-0195-0

    Screening with a small-molecule reactive-oxygen-species generator identifies the serine hydrolase enzyme ABHD12 as a lipase for the proapoptotic oxidized phoshatidylserine (ox-PS) lipids, which trigger production of proinflammatory cytokines. …read more

    Source:: Nature Biochemistry

          

    Complete reconstitution of the diverse pathways of gentamicin B biosynthesis

    Complete reconstitution of the diverse pathways of gentamicin B biosynthesis

    Complete reconstitution of the diverse pathways of gentamicin B biosynthesis, Published online: 14 January 2019; doi:10.1038/s41589-018-0203-4

    The reconstitution of gentamicin B biosynthesis reveals the existence of multiple new intermediates and branching pathways and enables the identification of factors that contribute to the low levels of the natural product in the native producer. …read more

    Source:: Nature Biochemistry

          

    Discovery of a ZIP7 inhibitor from a Notch pathway screen

    Discovery of a ZIP7 inhibitor from a Notch pathway screen

    Discovery of a ZIP7 inhibitor from a Notch pathway screen, Published online: 14 January 2019; doi:10.1038/s41589-018-0200-7

    A cell-based phenotypic screen identifying inhibitors of Notch signaling led to the discovery of NVS-ZP7-4, which blocks the activity of the zinc transporter SLC39a7 (ZIP7) and induces cell death through an ER stress mechanism. …read more

    Source:: Nature Biochemistry

          

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