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    Biochemistry

    O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response

    O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response

    O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response, Published online: 20 August 2018; doi:10.1038/s41589-018-0120-6

    O-GlcNAcylation of translation initiation factor component eIF4GI blocks interactions to poly(A)-binding protein Pab1 to induce disassembly of stress granules, releasing Hsp70-induced mRNAs and leading to translation of protective proteins …read more

    Source:: <a href=http://feeds.nature.com/~r/nchembio/rss/current/~3/ucCZBRJH6Bg/s41589-018-0120-6 target="_blank" title="O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response” rel=nofollow>Nature Biochemistry

          

    Continuous directed evolution of proteins with improved soluble expression

    Continuous directed evolution of proteins with improved soluble expression

    Continuous directed evolution of proteins with improved soluble expression, Published online: 20 August 2018; doi:10.1038/s41589-018-0121-5

    Through use of a split-intein pIII, soluble expression phage-assisted continuous evolution (SE-PACE) enables two simultaneous positive selections to rapidly evolve proteins with improved expression while maintaining their desired activities. …read more

    Source:: Nature Biochemistry

          

    ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands

    ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands

    ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands, Published online: 17 August 2018; doi:10.1038/s41589-018-0114-4

    Structural analysis of PRPP and ppGpp riboswitches reveals that they employ a helical element to create a tunnel for the ligand, whose specificity is determined by the conserved nucleotides forming the tunnel and long-distance contacts. …read more

    Source:: <a href=http://feeds.nature.com/~r/nchembio/rss/current/~3/vDna0TEGEyE/s41589-018-0114-4 target="_blank" title="ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands” rel=nofollow>Nature Biochemistry

          

    Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin

    Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin

    Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin, Published online: 17 August 2018; doi:10.1038/s41589-018-0115-3

    NMR and in vitro reconstitution indicate that GPCRs signal through SH3-containing proteins downstream of β-arrestin 1 proline regions and that arrestin allosterically activates downstream kinases by disrupting their autoinhibitory conformation. …read more

    Source:: Nature Biochemistry

          

    An optical sensor to monitor dynamics of extracellular glycine

    An optical sensor to monitor dynamics of extracellular glycine

    An optical sensor to monitor dynamics of extracellular glycine, Published online: 17 August 2018; doi:10.1038/s41589-018-0123-3

    A computational design approach was used to develop a genetically encoded FRET-based optical sensor that is aimed at monitoring extracellular glycine levels in brain tissue with the sensitivity and resolution to discern differences in dendritic spine and shaft environment and concentration dynamics upon afferent stimulation. …read more

    Source:: Nature Biochemistry

          

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