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    Biochemistry

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    BiochemistryDOI: 10.1021/acs.biochem.8b00471 [...]
    Mon, Aug 20, 2018
    Source: ACS Biochemistry Category: BIOCHEMISTRY
    TOC Graphic
    BiochemistryDOI: 10.1021/acs.biochem.8b00472 [...]
    Mon, Aug 20, 2018
    Source: ACS Biochemistry Category: BIOCHEMISTRY
    O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock responseO-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response, Published online: 20 August 2018; doi:10.1038/s41589-018-0120-6O-GlcNAcylation of translation initiation factor component eIF4GI blocks interactions to poly(A)-binding protein Pab1 to induce disassembly of stress granules, releasing Hsp70-induced mRNAs and leading to translation of protective proteins [...]
    Mon, Aug 20, 2018
    Source: Nature Biochemistry Category: BIOCHEMISTRY
    Author Correction: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probesAuthor Correction: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes, Published online: 20 August 2018; doi:10.1038/s41589-018-0040-5Author Correction: Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes [...]
    Mon, Aug 20, 2018
    Source: Nature Biochemistry Category: BIOCHEMISTRY
    Continuous directed evolution of proteins with improved soluble expressionContinuous directed evolution of proteins with improved soluble expression, Published online: 20 August 2018; doi:10.1038/s41589-018-0121-5Through use of a split-intein pIII, soluble expression phage-assisted continuous evolution (SE-PACE) enables two simultaneous positive selections to rapidly evolve proteins with improved expression while maintaining their desired activities. [...]
    Mon, Aug 20, 2018
    Source: Nature Biochemistry Category: BIOCHEMISTRY
    ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligandsykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands, Published online: 17 August 2018; doi:10.1038/s41589-018-0114-4Structural analysis of PRPP and ppGpp riboswitches reveals that they employ a helical element to create a tunnel for the ligand, whose specificity is determined by the conserved nucleotides forming the tunnel and long-distance contacts. [...]
    Fri, Aug 17, 2018
    Source: Nature Biochemistry Category: BIOCHEMISTRY
    A ribonucleotide trapA ribonucleotide trap, Published online: 17 August 2018; doi:10.1038/s41589-018-0127-zA ribonucleotide trap [...]
    Fri, Aug 17, 2018
    Source: Nature Biochemistry Category: BIOCHEMISTRY
    Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestinAllosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin, Published online: 17 August 2018; doi:10.1038/s41589-018-0115-3NMR and in vitro reconstitution indicate that GPCRs signal through SH3-containing proteins downstream of β-arrestin 1 proline regions and that arrestin allosterically activates downstream kinases by disrupting their autoinhibitory conformation. [...]
    Fri, Aug 17, 2018
    Source: Nature Biochemistry Category: BIOCHEMISTRY
    An optical sensor to monitor dynamics of extracellular glycineAn optical sensor to monitor dynamics of extracellular glycine, Published online: 17 August 2018; doi:10.1038/s41589-018-0123-3A computational design approach was used to develop a genetically encoded FRET-based optical sensor that is aimed at monitoring extracellular glycine levels in brain tissue with the sensitivity and resolution to discern differences in dendritic spine and shaft environment and concentration dynamics upon afferent stimulation. [...]
    Fri, Aug 17, 2018
    Source: Nature Biochemistry Category: BIOCHEMISTRY
    Catch and identify your preyCatch and identify your prey, Published online: 17 August 2018; doi:10.1038/s41589-018-0125-1Catch and identify your prey [...]
    Fri, Aug 17, 2018
    Source: Nature Biochemistry Category: BIOCHEMISTRY
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