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    Biochemistry

    Nature Chemical Biology, Published online: 06 April 2020; doi:10.1038/s41589-020-0506-0A highly selective inhibitor of the DCLK1/2 kinases is used to uncover the consequences of DCLK1 inhibition on viability, phosphosignaling and the transcriptome in patient-derived organoid models of pancreatic ductal adenocarcinoma. [...]
    Mon, Apr 06, 2020
    Source: Nature Biochemistry Category: BIOCHEMISTRY
    Nature Chemical Biology, Published online: 06 April 2020; doi:10.1038/s41589-020-0510-4Drug combinations consisting of two cell death-targeting drugs are enriched for antagonism and ‘single-agent dominance', where the faster-acting drug suppresses the slower-acting drug due to inhibitory crosstalk between cell death pathways. [...]
    Mon, Apr 06, 2020
    Source: Nature Biochemistry Category: BIOCHEMISTRY
    Nature Chemical Biology, Published online: 06 April 2020; doi:10.1038/s41589-020-0507-zSystematic characterization of codons using the unnatural base pair dNaM·dTPT3 leads to the discovery of nine new functional codon–anticodon pairs, three of which are shown to be orthogonally decoded by ribosomes and allow incorporation of up to three noncanonical amino acids in Escherichia coli. [...]
    Mon, Apr 06, 2020
    Source: Nature Biochemistry Category: BIOCHEMISTRY
    Nature Chemical Biology, Published online: 06 April 2020; doi:10.1038/s41589-020-0522-0Using new letters of DNA to encode information promises to expand the genetic code in a transformative way. A new semisynthetic organism has been created that uses 67 codons for protein biosynthesis, with three new codons based on unnatural nucleotides. [...]
    Mon, Apr 06, 2020
    Source: Nature Biochemistry Category: BIOCHEMISTRY
    Nature Chemical Biology, Published online: 06 April 2020; doi:10.1038/s41589-020-0509-xSynthetic circuit-host interactions affect the performance synthetic biology systems. Analysis of two bi-stable switch circuits reveals differential effects of host growth on circuit memory, which is dependent on the network topology of the circuit. [...]
    Mon, Apr 06, 2020
    Source: Nature Biochemistry Category: BIOCHEMISTRY
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    BiochemistryDOI: 10.1021/acs.biochem.0c00110 [...]
    Thu, Apr 02, 2020
    Source: ACS Biochemistry Category: BIOCHEMISTRY
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    BiochemistryDOI: 10.1021/acs.biochem.0c00073 [...]
    Thu, Apr 02, 2020
    Source: ACS Biochemistry Category: BIOCHEMISTRY
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    BiochemistryDOI: 10.1021/acs.biochem.0c00035 [...]
    Tue, Mar 31, 2020
    Source: ACS Biochemistry Category: BIOCHEMISTRY
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    BiochemistryDOI: 10.1021/acs.biochem.0c00104 [...]
    Tue, Mar 31, 2020
    Source: ACS Biochemistry Category: BIOCHEMISTRY
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