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    MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG

    MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG

    MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG, Published online: 08 October 2018; doi:10.1038/s41589-018-0136-y

    High intracellular concentrations of the α-ketoglutarate analog N-oxalylglycine, owing to MCT2-mediated transport of its newly described prodrug MOG, inhibit multiple enzymes in glutamine metabolism and selectively kill MCT2-expressing cancer cells. …read more

    Source:: Nature Biochemistry

          

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