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Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle

Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle

Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle, Published online: 09 July 2018; doi:10.1038/s41589-018-0096-2

Use of NMR to monitor MHC-I dynamics upon binding to the MHC-I chaperone TAPBPR explains the selection of optimal peptide sequences and release of the chaperone from the ternary peptide-MHC-I–TAPBPR complex. …read more

Source:: Nature Biochemistry

      

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